Since a native PSP ISO doesn't exist, here is how the community is currently running the game on mobile:
These handheld PCs run the official Mafia II (Classic) and Definitive Edition perfectly. mafia 2 ppsspp iso file download new
Extract the file (if it is in .zip or .7z format) to get the .iso file. Step 4: Launch the PPSSPP app. Since a native PSP ISO doesn't exist, here