If you are playing the app or browser version, don't scroll endlessly. Use the search function to hide elements you've already combined so you only see your "raw materials."
Some items are "Final Elements" and cannot be combined further. In Alchemy 10, these are often marked to save you time and frustration. Alchemy 10 - Free download and play on Windows alchemy 10 cheat sheet hot
, where specific items categorized under "Hot" or "Heat" are essential for progression. If you are playing the app or browser