Functional GI disorders (IBS, functional dyspepsia) are no longer considered "diagnoses of exclusion." The new edition integrates the latest Rome IV criteria and dedicates entire chapters to the neuroscience of the gut-brain axis. You will find updated algorithms for managing refractory IBS, including the role of dietary interventions (low FODMAP), gut-directed hypnotherapy, and novel pharmacological agents like tenapanor and ibodutant.

The 12th edition of Sleisenger and Fordtran's Gastrointestinal and Liver Disease has been thoroughly revised and updated to reflect the latest advances in the field. Some of the key features of this edition include: